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Scientist, Oligonucleotide Synthesis

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GSK

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Location:
United States , Cambridge

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Category:
Research and Development

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Contract Type:
Not provided

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Salary:

96525.00 - 160875.00 USD / Year
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Job Description:

The successful candidate will help to establish pre-clinical capabilities within GSK’s growing oligonucleotide synthesis lab. Areas of focus are SPOS of modalities such as ASOs, siRNA, SSO, and RNA editors screening, high-throughput automation, conjugates, and method development. Your expertise will enable us to solve complex chemical challenges, pushing the boundaries of what’s possible in oligonucleotide therapeutics. This role will provide YOU the opportunity to lead key activities to progress YOUR career.

Job Responsibility:

  • Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries
  • Perform hands-on work, maintain high-throughput automation workflows in support of routine and next generation chemistry and oligo method development
  • Maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high-quality, reproducible results
  • Work with the oligo analytical and delivery chemistry teams to ensure accountability and excellence in oligonucleotide and conjugate synthesis
  • Collaborate with various teams to achieve synthetic project goals

Requirements:

  • MS with 2+ or BS with 4+ years of experience in chemistry or chemical biology or related field
  • 2+ years of experience in modern synthetic chemistry methods, particularly nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis
  • Familiarity with Mermade 192X with Poseidon software and ÄKTA Oligosynt synthesizers, Cytiva, ÄKTA Avant and Pure purification systems with Unicorn software, and LC/HRMS, UPHLC, LC/MS analytics
  • Proficiency in oligonucleotide synthesis (SPOS), and biological understanding of RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors)

Nice to have:

  • Team-focused with strong initiative and ability to troubleshoot challenges and implement new solutions
  • Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team are required
  • Experience with oligonucleotide conjugation chemistries is desirable but not required
  • Sense of urgency, flexibility, independence and accountability
  • Ability to communicate both verbally and in writing with all levels both inside and outside of organization
  • Maintain a high level of integrity while balancing multiple priorities and responsibilities
  • Must be a committed team player prepared to work in and embrace a team-based culture
What we offer:
  • Competitive base salary
  • Annual bonus based on company performance
  • Flexible working options available for most roles
  • Learning and career development
  • Access to healthcare & wellbeing programmes
  • Employee recognition programmes
  • health care and other insurance benefits (for employee and family)
  • retirement benefits
  • paid holidays
  • vacation
  • paid caregiver/parental and medical leave
  • eligibility to participate in our share based long term incentive program

Additional Information:

Job Posted:
February 16, 2026

Employment Type:
Fulltime
Work Type:
On-site work
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