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Seeking an individual for a position in neuroimmunology for projects that encompasses basic and translational research. Work in the laboratory is centered around the complement system and neuroinflammatory mechanisms. Ongoing projects involve investigating acute and chronic neuroimmune responses occurring after stroke or after different types of traumatic brain injury, including the long-term neurodegenerative sequalae of injury. For this position, work will be focused on mouse models of stroke and traumatic brain injury. Other aspects of the project will include high resolution and confocal microscopy, cellular and molecular immune profile analysis, therapeutic evaluation of drugs, and detailed assessments of motor and cognitive functions. The laboratory is also developing novel transgenic animals for mechanistic studies, and is involved in the development (and commercialization) of novel therapeutic approaches.
Job Responsibility:
Participate in a project related to above described work, including perform surgical procedures
Prepare sections from mouse brains and process for histology and immune-microscopy
Perform various microscopy techniques
Evaluate mice via various behavioral tasks
Perform high dimensional analyses of post-injury immune landscape, analyze and interpret data
Will also involve use of image analysis software and generation of computer images
Determine behavioral outcomes in terms of pathophysiological findings
Collaborate with other lab personnel in related projects
Participate in lab meetings and project-specific meetings with other lab personnel
Keep records and up to date lab notebook/lab archives
Assist with writing manuscripts and grants
Keep up to date with relevant literature
Requirements:
PhD degree in biology or other natural, life or health care science related to the assigned area of research
For candidates with previous experience with the mouse middle cerebral artery occlusion model, a Bachelor’s degree is sufficient
Preferably with microsurgical experience
Ideally, experience with the murine middle cerebral artery occlusion model
Ability to perform job functions in an upright position
Ability to perform job functions in a seated position
Ability to perform job functions while walking/mobile
Ability to climb stairs
Ability to work indoors
Ability to work in all cold temperature extremes
Ability to bend at the waist
Ability to twist at the waist
Ability to perform 'pinching' operations
Ability to fully use both hands/arms
Ability to perform repetitive motions with hands/wrists/elbows and shoulders
Ability to fully use both legs
Ability to reach in all directions
Possess good finger dexterity
Ability to maintain tactile sensory functions
Ability to maintain good olfactory sensory function
Ability to lift and carry 15 lbs., unassisted
Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted
Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted
Ability to push/pull objects, up to 15 lbs., unassisted
Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings
Ability to maintain 20/40 vision, corrected
Ability to see and recognize objects close at hand
Ability to see and recognize objects at a distance
Ability to match or discriminate between colors
Ability to determine distance/relationship between objects
depth perception
Good peripheral vision capabilities
Ability to maintain hearing acuity, with correction
Ability to perform gross motor functions with frequent fine motor movements
Ability to be qualified physically (by medical personnel) for respirator use, initially and annually
Ability to work alone in isolated areas, such as darkrooms
Ability to obtain and maintain a valid drivers license
Computer literacy
Ability to work rotating shifts as required
Ability to work overtime as required
Ability to learn and use new processes, tools and equipment as required
Nice to have:
Microsurgical experience
Experience with the murine middle cerebral artery occlusion model