Doctoral candidate

Secretory immunoglobulins A and M (SIg) are key players in intestinal homeostasis, as they modulate the composition of the gut microbiota. In patients with inflammatory bowel diseases (IBD), SIg display altered glycosylation patterns associated with dysbiosis and defects in immune responses. This PhD project aims to elucidate how SIg glycosylation reprograms intestinal immune responses and shapes the gut microbiota, particularly in the context of IBD. SIg glycosylation patterns of patients will be analyzed and correlated with gut microbiota composition. Using murine models of IBD, the candidate will determine whether specific SIg glycosylation patterns promote or exacerbate intestinal inflammation. Finally, the factors controlling SIg glycosylation will be identified. In particular, the respective roles of the microbiota and inflammation will be evaluated.